Welcome to the MacCoss Lab!

We are a protein mass spectrometry lab located in the Department of Genome Sciences at the University of Washington in Seattle.

The focus of our research is in the development of stable isotope and mass spectrometry based approaches to improve our understanding of biology on a molecular, cellular, and whole organism level. Presently, individuals in the laboratory are working on technology for

These technologies are being demonstrated and tested in the model organisms C. elegans and S. cerevisiae. Although our current research interests are presently in model systems, our long-term goal is to have technologies robust enough to handle the automated high-throughput characterization of human clinical samples.

Contribute to Research in the MacCoss Lab

The MacCoss lab has developed a number of technologies and software tools that improve the way proteins are characterized in health and disease. If you feel like you have benefited from one or more of tools (i.e. Skyline) and would like to see their continued development, support, and/or training -- consider making a tax deductable donation.

Recent News & Updates

January 20, 2011

Brendan MacLean writes a Tech Talk Article for USHUPO

Brendan wrote an excellent short article providing tips for users of our Skyline software. This short article provides excellent advice from his and Daniela Tomazela's experience in establishing targeted proteomics methods.

September 30, 2010

Jarrett Egertson is Awarded an NIH/NRSA F31 Fellowship

Jarrett was awarded a predoctoral fellowship to develop and apply mass spectrometry technologies to study the molecular mechanisms of aging.

September 15, 2010

Skyline v0.7 Released

We released an update to our targeted proteomics software Skyline. This version has significantly improved handling of PTMs and neutral losses, multi-select copy and paste, support for multiple heavy isotope labels, Native Waters file import, library building from Protein Pilot, and a lot more. For more information ...

May 21, 2010

Collaboration with ThermoFisher to produce proteins

We are using a new in vitro transcription/translation product from Pierce to produce proteins from the human genome. These proteins will be used to expedite the development and optimization of targeted SRM assays. For more information see an article written at the Proteomonitor.

March 17, 2010

Skyline v0.6 Released

We released an update to our targeted proteomics software Skyline. This version has improved peak detection, collision energy optimization, peak area chards, peptide summary charts, and much much more. For more information ...

Sept 24, 2009

Skyline v0.5 Released

The latest release of our popular software tool for building Selected Reaction Monitoring (SRM) / Multiple Reaction Monitoring (MRM) methods and analyzing the resulting mass spectrometer data. More ...

May 2009

Interview by Environmental Health Perspective

Discussion on the use of targeted proteomics for the analysis of environmental toxicants on proteins. More ...

Feb 26, 2009

MacCoss honored at UW Early Career Award Recognition

Four Assistant Professors recognized for winning national awards. More ...

Dec 19, 2008

Mike MacCoss wins 2007 PECASE Award

The Presidential Early Career Award for Scientists and Engineers is the nation's highest honor for scientists at the onset of their careers.

NIH Press Release
UW Press Release

Older News & Updates